杀粉蝶霉素A Piericidin A
NADH-ubiquinone oxidoreductase inhibitor
Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (*plex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
PRODUCT PROPERTIES
|
Alternative Name:
|
Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D
|
|
|
RTECS:
|
YD4588000
|
|
|
Source/Host:
|
Isolated from Streptomyces sp. MST-AS5364.
|
|
|
Solubility:
|
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
|
|
|
Long Term Storage:
|
-20°C
|
|
|
Hazard:
|
VERY TOXIC.
|
|
|
MW:
|
415.6
|
|
|
CAS:
|
2738-64-9
|
|
|
Formula:
|
C25H37NO4
|
|
|
Purity:
|
≥95% (HPLC)
|
|
|
Appearance:
|
Pale yellow oil.
|
普华仕科技发展有限公司 --Puhuashi Technology Development Co., Ltd
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
索取产品详细资料，查询更多其它产品，
请致电：010-61242659、60211811，
写邮件至：sales@puhs-tech.*，
或进入我司网站***.puhs-tech.*首页“在线客服”“在线留言”系统，
我们的客服人员会尽快回复您。
客服QQ：1446645907、1747853905、2627176950、1826321165
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~